Ontology highlight
ABSTRACT:
SUBMITTER: Brulotte ML
PROVIDER: S-EPMC5717197 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Brulotte Melissa L ML Jeong Byung-Cheon BC Li Faxiang F Li Bing B Yu Eric B EB Wu Qiong Q Brautigam Chad A CA Yu Hongtao H Luo Xuelian X
Nature communications 20171205 1
The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-Mad2), bound to Cdc20. C-Mad2-Cdc20 is incorporated into the mitotic checkpoint complex (MCC), which inhibits the anaphase-promoting complex/cyclosome (APC/C). The C-Mad2-binding protein p31<sup>comet</sup> and the ATPase TRIP13 promote MCC disassembly and checkpoint silencing. Here, using n ...[more]