The Alzheimer's disease metabolic brain pattern in mild cognitive impairment.
Ontology highlight
ABSTRACT:
SUBMITTER: Meles SK
PROVIDER: S-EPMC5718332 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Publications
The Alzheimer's disease metabolic brain pattern in mild cognitive impairment.
Meles Sanne K SK Pagani Marco M Arnaldi Dario D De Carli Fabrizio F Dessi Barbara B Morbelli Silvia S Sambuceti Gianmario G Jonsson Cathrine C Leenders Klaus L KL Nobili Flavio F
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170920 12
We investigated the expression of the Alzheimer's disease-related metabolic brain pattern (ADRP) in <sup>18</sup>F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer's disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to cont ...[more]
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