Dataset Information

Association between exercise and the risk of dementia: results from a nationwide longitudinal study in China.

ABSTRACT: OBJECTIVE:This study was conducted to examine the causal association between exercise and the risk of dementia among older Chinese adults. DESIGN:Longitudinal population-based study with a follow-up duration of 9 years. SETTING:Data for the Chinese Longitudinal Healthy Longevity Survey waves occurring from 2002 to 2011-2012 were extracted from the survey database. PARTICIPANTS:In total, 7501 dementia-free subjects who were older than 65 years were included at baseline. Dementia was defined as a self-reported or proxy-reported physician's diagnosis of the disease. OUTCOME MEASURES AND METHODS:Regular exercise and potential confounding variables were obtained via a self-report questionnaire. We generated longitudinal logistic regression models based on time-lagged generalised estimating equation to examine the causal association between exercise and dementia risk. RESULTS:Of the 7501 older Chinese people included in this study, 338 developed dementia during the 9-year follow-up period after excluding those who were lost to follow-up or deceased. People who regularly exercised had lower odds of developing dementia (OR=0.53, 95% CI 0.33?to 0.85) than those who did not exercise regularly. CONCLUSION:Regular exercise was associated with decreased risk of dementia. Policy-makers should develop effective public health programmes and build exercise-friendly environments for the general public.

SUBMITTER: Zhou Z

PROVIDER: S-EPMC5719269 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Association between exercise and the risk of dementia: results from a nationwide longitudinal study in China.

Zhou Zi Z Fu Jian J Hong Y Alicia YA Wang Ping P Fang Ya Y

BMJ open 20171204 12

<h4>Objective</h4>This study was conducted to examine the causal association between exercise and the risk of dementia among older Chinese adults.<h4>Design</h4>Longitudinal population-based study with a follow-up duration of 9 years.<h4>Setting</h4>Data for the Chinese Longitudinal Healthy Longevity Survey waves occurring from 2002 to 2011-2012 were extracted from the survey database.<h4>Participants</h4>In total, 7501 dementia-free subjects who were older than 65 years were included at baselin ...[more]

PMID: 29208615

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Project description:BackgroundFew multicity studies have evaluated the association between cold spells and mortality risk and burden.ObjectivesWe aimed to estimate the association between cold spells and cause-specific mortality and to evaluate the mortality burden in China.MethodsWe conducted a time-series analysis with a nationally representative Disease Surveillance Points System database during the cool seasons spanning from 2013 to 2015 in 272 Chinese cities. We used 12 cold-spell definitions and overdispersed generalized additive models with distributed lag models to estimate the city-specific cumulative association of cold spells over lags of 0-28 d. We controlled for the nonlinear and lagged effects of cold temperature over 0-28 d to evaluate the added effect estimates of cold spell. We also quantified the nationwide mortality burden and pooled the estimated association at national and different climatic levels with meta-regression models.ResultsFor the cold-spell definition of daily mean temperatures of ≤5th percentile of city-specific daily mean temperature and duration of ≥4 consecutive d, the relative risks (i.e., risk ratios) associated with cold spells were 1.39 [95% confidence interval (CI): 1.15, 1.69] for non-accidental mortality, 1.66 (95% CI: 1.20, 2.31) for coronary heart disease mortality, 1.49 (95% CI: 1.12, 1.97) for stroke mortality, and 1.26 (95% CI: 0.85, 1.87) for chronic obstructive pulmonary disease mortality. Cold spells showed a maximal lagged association of 28 d with the risks peaked at 10-15 d. A statistically significant attributable fraction (AF) of non-accidental mortality [2.10% (95% CI: 0.94%, 3.04%)] was estimated. The risks were higher in the temperate continental and the temperate monsoon zones than in the subtropical monsoon zone. The elderly population was especially vulnerable to cold spells.DiscussionOur study provides evidence for the significant relative risks of non-accidental, cardiovascular, and respiratory mortality associated with cold spells. The findings on vulnerable populations and differential risks in different climatic zones may help establish region-specific forecasting systems against the hazardous impact of cold spells. https://doi.org/10.1289/EHP9284.

Dataset Information

Association between exercise and the risk of dementia: results from a nationwide longitudinal study in China.

Publications

Association between exercise and the risk of dementia: results from a nationwide longitudinal study in China.

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