Dataset Information

Functional visual fields: a cross-sectional UK study to determine which visual field paradigms best reflect difficulty with mobility function.

ABSTRACT: OBJECTIVES:To develop an appropriate method of assessing visual field (VF) loss which reflects its functional consequences, this study aims to determine which method(s) of assessing VF best reflect mobility difficulty. SETTING:This cross-sectional observational study took place within a single primary care setting. Participants attended a single session at a University Eye Clinic, Cambridge, UK, with data collected by a single researcher (HS), a qualified optometrist. PARTICIPANTS:50 adult participants with peripheral field impairment were recruited for this study. Individuals with conditions not primarily affecting peripheral visual function, such as macular degeneration, were excluded from the study. PRIMARY AND SECONDARY OUTCOME MEASURES:Participants undertook three custom and one standard binocular VF tests assessing VF to 60°, and also integrated monocular threshold 24-2 visual fields (IVF). Primary VF outcomes were average mean threshold, percentage of stimuli seen and VF area. VF outcomes were compared with self-reported mobility function assessed with the Independent Mobility Questionnaire, and time taken and patient acceptability were also considered. Receiver operating characteristic (ROC) curves determined which tests best predicted difficulty with mobility tasks. RESULTS:Greater VF loss was associated with greater self-reported mobility difficulty with all field paradigms (R2 0.38-0.48, all P<0.001). All four binocular tests were better than the IVF at predicting difficulty with at least three mobility tasks in ROC analysis. Mean duration of the tests ranged from 1?min 26?s (±9?s) for kinetic assessment to 9?min 23?s (±24?s) for IVF. CONCLUSIONS:The binocular VF tests extending to 60° eccentricity all relate similarly to self-reported mobility function, and slightly better than integrated monocular VFs. A kinetic assessment of VF area is quicker than and as effective at predicting mobility function as static threshold assessment.

SUBMITTER: Subhi H

PROVIDER: S-EPMC5719284 | biostudies-other | 2017 Nov

REPOSITORIES: biostudies-other

ACCESS DATA

Publications

Functional visual fields: a cross-sectional UK study to determine which visual field paradigms best reflect difficulty with mobility function.

Subhi Hikmat H Latham Keziah K Myint Joy J Crossland Michael M

BMJ open 20171120 11

<h4>Objectives</h4>To develop an appropriate method of assessing visual field (VF) loss which reflects its functional consequences, this study aims to determine which method(s) of assessing VF best reflect mobility difficulty.<h4>Setting</h4>This cross-sectional observational study took place within a single primary care setting. Participants attended a single session at a University Eye Clinic, Cambridge, UK, with data collected by a single researcher (HS), a qualified optometrist.<h4>Participa ...[more]

PMID: 29162576

Similar Datasets

Project description:Although current neuroscience and behavioral studies provide substantial understanding of tool representations (e.g., the processing of tool-related affordances) in the human brain, most of this knowledge is limited to right-handed individuals with typical organization of cognitive and manual skills. Therefore, any insights from these lines of research may be of little value in rehabilitation of patients with atypical laterality of praxis and/or hand dominance. To fill this gap, we tested perceptual processing of man-made objects in 18 healthy left-handers who were likely to show greater incidence of right-sided or bilateral (atypical) lateralization of functions. In the two experiments reported here, participants performed a tool vs. non-tool categorization task. In Experiment 1, target and distracter objects were presented for 200 ms in the left (LVF) or right (RVF) visual field, followed by 200 ms masks. In Experiment 2, the centrally presented targets were preceded by masked primes of 35 ms duration, again presented in the LVF or RVF. Based on results from both studies, i.e., response times (RTs) to correctly discriminated stimuli irrespective of their category, participants were divided into two groups showing privileged processing in either left (N = 9) or right (N = 9) visual field. In Experiment 1, only individuals with RVF advantage showed significantly faster categorization of tools in their dominant visual field, whereas those with LVF advantage revealed merely a trend toward such an effect. In Experiment 2, when targets were preceded by identical primes, the "atypical" group showed significantly facilitated categorization of non-tools, whereas the "typical" group demonstrated a trend toward faster categorization of tools. These results indicate that in subjects with atypically organized cognitive skills, tool-related processes are not just mirror reversed. Thus, our outcomes call for particular caution in neurorehabilitation directed at left-handed individuals.

Project description:BACKGROUND:Studying the determinants and the long-term consequences of fetal adipose accretion requires accurate assessment of neonatal body composition. In large epidemiological studies, in-depth body composition measurement methods are usually not feasible for cost and logistical reasons, and there is a need to identify anthropometric measures that adequately reflect neonatal adiposity. METHODS:In a multiethnic Asian mother-offspring cohort in Singapore, anthropometric measures (weight, length, abdominal circumference, skinfold thicknesses) were measured using standardized protocols in newborn infants, and anthropometric indices (weight/length, weight/length2 (body mass index, BMI), weight/length3 (ponderal index, PI)) derived. Neonatal total adiposity was measured using air displacement plethysmography (ADP) and abdominal adiposity using magnetic resonance imaging (MRI). Correlations of the anthropometric measures with ADP- and MRI-based adiposity were assessed using Pearson's correlation coefficients (rp), including in subsamples stratified by sex and ethnicity. RESULTS:Study neonates (n=251) had a mean (s.d.) age of 10.2 (2.5) days. Correlations between ADP-based fat mass (ADPFM) and anthropometric measures were moderate (rp range: 0.44-0.67), with the strongest being with weight/length, weight, BMI and sum of skinfolds (rp=0.67, 0.66, 0.62, 0.62, respectively, all P<0.01). All anthropometric measures except skinfold thicknesses correlated more strongly with ADP-based fat-free mass than ADPFM, indicating that skinfold measures may have more discriminative power in terms of neonatal total body adiposity. For MRI-based measures, weight and weight/length consistently showed strong positive correlations (rp?0.7) with abdominal adipose tissue compartments. These correlations were consistent in boys and girls, across different ethnic groups, and when conventional determinants of neonatal adiposity were adjusted for potential confounding. Abdominal circumference was not strongly associated with ADPFM or abdominal fat mass. CONCLUSIONS:Simple anthropometric measures (weight and weight/length) correlated strongly with neonatal adiposity, with some evidence for greater discriminative power for skinfold measures. These simple measures could be of value in large epidemiological studies.

Dataset Information

Functional visual fields: a cross-sectional UK study to determine which visual field paradigms best reflect difficulty with mobility function.

Publications

Functional visual fields: a cross-sectional UK study to determine which visual field paradigms best reflect difficulty with mobility function.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets