Ontology highlight
ABSTRACT:
SUBMITTER: Pennini ME
PROVIDER: S-EPMC5722860 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Pennini Meghan E ME De Marco Anna A Pelletier Mark M Bonnell Jessica J Cvitkovic Romana R Beltramello Martina M Cameroni Elisabetta E Bianchi Siro S Zatta Fabrizia F Zhao Wei W Xiao Xiaodong X Camara Maria M MM DiGiandomenico Antonio A Semenova Elena E Lanzavecchia Antonio A Warrener Paul P Suzich JoAnn J Wang Qun Q Corti Davide D Stover C Kendall CK
Nature communications 20171208 1
Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these pathogens are so successful is not fully understood. Robust antibacterial vaccines have prevented and reduced resistance suggesting a pivotal role for immunity in deterring antibiotic resistance. Here, we show the increased prevalence of Klebsiella pneumoniae lipopolysaccharide O2 serotype strains in all major drug resistance groups correlating with a paucity of anti-O2 antibodies in human B cell repertoires ...[more]