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Midgut neuroendocrine tumor presenting with acute intestinal ischemia.


ABSTRACT: Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors, commonly called carcinoids, account for about 2/3 of all neuroendocrine tumors, they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms, which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment.

SUBMITTER: Mantzoros I 

PROVIDER: S-EPMC5725304 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Midgut neuroendocrine tumor presenting with acute intestinal ischemia.

Mantzoros Ioannis I   Savvala Natalia Antigoni NA   Ioannidis Orestis O   Parpoudi Styliani S   Loutzidou Lydia L   Kyriakidou Despoina D   Cheva Angeliki A   Intzos Vasileios V   Tsalis Konstantinos K  

World journal of gastroenterology 20171201 45


Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors, commonly called carcinoids, account for about 2/3 of all neuroendocrine tumors, they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms, whi  ...[more]

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