Adaptation of mRNA structure to control protein folding.
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ABSTRACT:
SUBMITTER: Faure G
PROVIDER: S-EPMC5731814 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Publications
Adaptation of mRNA structure to control protein folding.
Faure Guilhem G Ogurtsov Aleksey Y AY Shabalina Svetlana A SA Koonin Eugene V EV
RNA biology 20170829 12
Comparison of mRNA and protein structures shows that highly structured mRNAs typically encode compact protein domains suggesting that mRNA structure controls protein folding. This function is apparently performed by distinct structural elements in the mRNA, which implies 'fine tuning' of mRNA structure under selection for optimal protein folding. We find that, during evolution, changes in the mRNA folding energy follow amino acid replacements, reinforcing the notion of an intimate connection bet ...[more]
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