Ontology highlight
ABSTRACT:
SUBMITTER: Jin DH
PROVIDER: S-EPMC5731892 | biostudies-other | 2017 Nov
REPOSITORIES: biostudies-other
Jin Dong Hao DH Kim Yujin Y Lee Bo Bin BB Han Joungho J Kim Hong Kwan HK Shim Young Mog YM Kim Duk-Hwan DH
Oncotarget 20171006 60
A target molecule responsible for cell cycle arrest by metformin was discovered using a gene chip array in lung cancer cells and the effect of metformin on E2F8 was assessed. The siRNA-mediated knockdown of E2F8 significantly suppressed G1-S progression while ectopic expression of E2F8 relieved metformin-induced G1 arrest. The mRNA levels of p21 were found to be inversely related to those of E2F8 in lung cancer cells while siRNA-mediated knockdown of p21 partly rescued siE2F8-induced arrest of t ...[more]