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Accelerated phase contrast flow imaging with direct complex difference reconstruction.

ABSTRACT: To propose and evaluate a new model-based reconstruction method for highly accelerated phase-contrast magnetic resonance imaging (PC-MRI) with sparse sampling.This work presents a new constrained reconstruction method based on low-rank and sparsity constraints to accelerate PC-MRI. More specifically, we formulate the image reconstruction problem into separate reconstructions of flow-reference image sequence and complex differences. We then utilize the joint partial separability and sparsity constraints to enable high quality reconstruction from highly undersampled (k,t)-space data. We further integrate the proposed method with ESPIRiT based parallel imaging model to effectively handle multichannel acquisition.The proposed method was evaluated with in vivo data acquired from both 2D and 3D PC flow imaging experiments, and compared with several state-of-the-art methods. Experimental results demonstrate that the proposed method leads to more accurate velocity reconstruction from highly undersampled (k,t)-space data, and particularly superior capability of capturing the peak velocity of blood flow. In terms of flow visualization, blood flow patterns obtained from the proposed reconstruction also exhibit better agreement with those obtained from the fully sampled reference.The proposed method achieves improved accuracy over several state-of-the-art methods for velocity reconstruction with highly accelerated (k,t)-space data. Magn Reson Med 77:1036-1048, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Sun A

PROVIDER: S-EPMC5734924 | biostudies-other | 2017 Mar

REPOSITORIES: biostudies-other

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Accelerated phase contrast flow imaging with direct complex difference reconstruction.

Sun Aiqi A Zhao Bo B Ma Ke K Zhou Zechen Z He Le L Li Rui R Yuan Chun C

Magnetic resonance in medicine 20160326 3

<h4>Purpose</h4>To propose and evaluate a new model-based reconstruction method for highly accelerated phase-contrast magnetic resonance imaging (PC-MRI) with sparse sampling.<h4>Theory and methods</h4>This work presents a new constrained reconstruction method based on low-rank and sparsity constraints to accelerate PC-MRI. More specifically, we formulate the image reconstruction problem into separate reconstructions of flow-reference image sequence and complex differences. We then utilize the j ...[more]

PMID: 27016025

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Project description:PurposeCardiovascular diseases remain the number one death cause worldwide. Preclinical 4D flow phase contrast magnetic resonance imaging can provide substantial insights in the analysis of aortic pathophysiologies in various animal models. These insights may allow a better understanding of pathophysiologies, therapy monitoring, and can possibly be translated to humans. This study provides a framework to acquire the velocity field within the aortic arch. It analyses important flow values at different locations within the aortic arch. Imaging parameters with high temporal and spatial resolution are provided, that still allow combining this time-consuming method with other necessary imaging-protocols.MethodsA new setup was established where a prospectively gated 4D phase contrast sequence is combined with a highly sensitive cryogenic coil on a preclinical magnetic resonance scanner. The sequence was redesigned to maintain a close to steady state condition of the longitudinal magnetization and hence to overcome steady state artifacts. Imaging parameters were optimized to provide high spatial and temporal resolution. Pathline visualizations were generated from the acquired velocity data in order to display complex flow patterns.ResultsOur setup allows data acquisition with at least two times the rate than that of previous publications based on Cartesian encoding, at an improved image quality. The "steady state" sequence reduces observed artifacts and provides uniform image intensity over the heart cycle. This made possible quantification of blood speed and wall shear stress (WSS) within the aorta and its branches. The highest velocities were observed in the ascending aorta with 137.5 ± 8 cm/s. Peak velocity values in the Brachiocephalic trunk were 57 ± 12 cm/s. Quantification showed that the peak flow occurs around 20 ms post R-wave in the ascending aorta. The highest mean axial wall shear stress was observed in the analysis plane between the left common carotid artery (LCCA) and the left subclavian artery. A stable image quality allows visualizing complex flow patterns by means of streamlines and for the first time, to the best of our knowledge, pathline visualizations from 4D flow MRI in mice.ConclusionThe described setup allows analyzing pathophysiologies in mouse models of cardiovascular diseases in the aorta and its branches with better image quality and higher spatial and temporal resolution than previous Cartesian publications. Pathlines provide an advanced analysis of complex flow patterns in the murine aorta. An imaging protocol is provided that offers the possibility to acquire the aortic arch at sufficiently high resolution in less than one hour. This allows the combination of the flow assessment with other multifunctional imaging protocols.

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Accelerated phase contrast flow imaging with direct complex difference reconstruction.

Publications

Accelerated phase contrast flow imaging with direct complex difference reconstruction.

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