Ontology highlight
ABSTRACT:
SUBMITTER: Yi S
PROVIDER: S-EPMC5735811 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Yi Shaohua S Long Fei F Cheng Juanbo J Huang Daixin D
BMC molecular biology 20171219 1
<h4>Background</h4>Methylation analysis of cell-free DNA is a encouraging tool for tumor diagnosis, monitoring and prognosis. Sensitivity of methylation analysis is a very important matter due to the tiny amounts of cell-free DNA available in plasma. Most current methods of DNA methylation analysis are based on the difference of bisulfite-mediated deamination of cytosine between cytosine and 5-methylcytosine. However, the recovery of bisulfite-converted DNA based on current methods is very poor ...[more]