Ontology highlight
ABSTRACT:
SUBMITTER: Vzorov AN
PROVIDER: S-EPMC5736137 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Vzorov Andrei N AN Compans Richard W RW
Archives of virology 20160803 11
We defined the effects of the cytoplasmic domain (CT) of the Env glycoprotein on co-receptor usage of HIV-1 by reciprocal exchanges of regions containing V3-V5 loops between CD4-dependent and CD4-independent isolates. Primary HIV-1 isolate Env clones CD8 CXCR4-tropic 92UG046 CT84 with an 84-aa truncated CT domain, CD4 CXCR4-tropic 92UG046, and CD4 CCR5-tropic SF162 with full-length (FL) CT domains were used for comparison. The parental 92UG046 Env with CT84 was not fusogenic, but a chimeric SF16 ...[more]