Ontology highlight
ABSTRACT:
SUBMITTER: Zhang A
PROVIDER: S-EPMC5736810 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Zhang Angelica A Veesenmeyer Jeffrey L JL Hauser Alan R AR
Infection and immunity 20171219 1
The <i>Pseudomonas aeruginosa</i> type III secretion system delivers effector proteins directly into target cells, allowing the bacterium to modulate host cell functions. ExoU is the most cytotoxic of the known effector proteins and has been associated with more severe infections in humans. ExoU is a patatin-like A<sub>2</sub> phospholipase requiring the cellular host factors phosphatidylinositol 4,5-bisphosphate [PI(4,5)P<sub>2</sub>] and ubiquitin for its activation <i>in vitro</i> We demonstr ...[more]