Bronchial biopsy specimen as a surrogate for DNA methylation analysis in inoperable lung cancer.
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ABSTRACT:
SUBMITTER: Um SW
PROVIDER: S-EPMC5738682 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Publications
Bronchial biopsy specimen as a surrogate for DNA methylation analysis in inoperable lung cancer.
Um Sang-Won SW Kim Hong Kwan HK Kim Yujin Y Lee Bo Bin BB Kim Dongho D Han Joungho J Kim Hojoong H Shim Young Mog YM Kim Duk-Hwan DH
Clinical epigenetics 20171220
<h4>Background</h4>This study was aimed at understanding whether bronchial biopsy specimen can be used as a surrogate for DNA methylation analysis in surgically resected lung cancer.<h4>Methods</h4>A genome-wide methylation was analyzed in 42 surgically resected tumor tissues, 136 bronchial washing, 12 sputum, and 8 bronchial biopsy specimens using the Infinium HumanMethylation450 BeadChip, and models for prediction of lung cancer were evaluated using TCGA lung cancer data.<h4>Results</h4>Four t ...[more]
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