Ontology highlight
ABSTRACT:
SUBMITTER: Chiba K
PROVIDER: S-EPMC5739300 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Chiba Kyoko K Chien Ko-Yi KY Sobu Yuriko Y Hata Saori S Kato Shun S Nakaya Tadashi T Okada Yasushi Y Nairn Angus C AC Kinjo Masataka M Taru Hidenori H Wang Rong R Suzuki Toshiharu T
Molecular biology of the cell 20171101 26
In neurons, amyloid β-protein precursor (APP) is transported by binding to kinesin-1, mediated by JNK-interacting protein 1b (JIP1b), which generates the enhanced fast velocity (EFV) and efficient high frequency (EHF) of APP anterograde transport. Previously, we showed that EFV requires conventional interaction between the JIP1b C-terminal region and the kinesin light chain 1 (KLC1) tetratricopeptide repeat, whereas EHF requires a novel interaction between the central region of JIP1b and the coi ...[more]