Ontology highlight
ABSTRACT:
SUBMITTER: Sivanand S
PROVIDER: S-EPMC5741483 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Sivanand Sharanya S Viney Isabella I Wellen Kathryn E KE
Trends in biochemical sciences 20171123 1
The epigenome is sensitive to the availability of metabolites that serve as substrates of chromatin-modifying enzymes. Links between acetyl-CoA metabolism, histone acetylation, and gene regulation have been documented, although how specificity in gene regulation is achieved by a metabolite has been challenging to answer. Recent studies suggest that acetyl-CoA metabolism is tightly regulated both spatially and temporally to elicit responses to nutrient availability and signaling cues. Here we dis ...[more]