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Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study.


ABSTRACT: In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE.We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event.Twenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P?=?0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety.Serum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.

SUBMITTER: Ferreira I 

PROVIDER: S-EPMC5741886 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study.

Ferreira Isabel I   Croca Sara S   Raimondo Maria Gabriella MG   Matharu Manjit M   Miller Sarah S   Giles Ian I   Isenberg David D   Ioannou Yiannis Y   Hanly John G JG   Urowitz Murray B MB   Anderson Nicole N   Aranow Cynthia C   Askanase Anca A   Bae Sang-Cheol SC   Bernatsky Sasha S   Bruce Ian N IN   Buyon Jill J   Clarke Ann E AE   Dooley Mary Anne MA   Fortin Paul P   Ginzler Ellen E   Gladman Dafna D   Gordon Caroline C   Inanc Murat M   Jacobsen Søren S   Kalunian Kenneth K   Kamen Diane D   Khamashta Munther M   Lim Sam S   Manzi Susan S   Merrill Joan J   Nived Ola O   Peschken Christine C   Petri Michelle M   Ramsey-Goldman Rosalind R   Ruiz-Irastorza Guillermo G   Sanchez-Guerrero Jorge J   Steinson Kristjan K   Sturfelt Gunnar K GK   van Vollenhoven Ronald R   Wallace Daniel J DJ   Zoma Asad A   Rahman Anisur A  

Arthritis research & therapy 20171222 1


<h4>Background</h4>In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE.<h4>Meth  ...[more]

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