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Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia.

ABSTRACT: Three new sulfated steroidal glycosides (3-5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI50 values down to 0.49 ?M) against the K562 human leukemia cell line.

SUBMITTER: Lee YJ

PROVIDER: S-EPMC5742839 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Three New Cytotoxic Steroidal Glycosides Isolated from Conus pulicarius Collected in Kosrae, Micronesia.

Lee Yeon-Ju YJ Han Saem S Kim Su Hyun SH Lee Hyi-Seung HS Shin Hee Jae HJ Lee Jong Seok JS Lee Jihoon J

Marine drugs 20171204 12

Three new sulfated steroidal glycosides (3-5), along with known cholesterol derivatives (1,2), were isolated from the visceral extract of the cone snail Conus pulicarius. The structure of each new compound was elucidated by nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The three new compounds exhibited significant in vitro cytotoxicity (GI50 values down to 0.49 μM) against the K562 human leukemia cell line. ...[more]

PMID: 29207558

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