Ontology highlight
ABSTRACT:
SUBMITTER: Salerno SN
PROVIDER: S-EPMC5744174 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
CPT: pharmacometrics & systems pharmacology 20171025 12
Solithromycin is a fluoroketolide antibiotic under investigation for community-acquired bacterial pneumonia (CABP). We developed a whole-body physiologically based pharmacokinetic (PBPK) model for solithromycin in adults using PK-Sim and MoBi version 6.2, which incorporated time-dependent CYP3A4 auto-inhibition. The model was developed and evaluated using plasma and epithelial lining fluid (ELF) concentration data from 100 healthy subjects and 22 patients with CABP (1,966 plasma, 30 ELF samples) ...[more]