Ontology highlight
ABSTRACT:
SUBMITTER: Sulciner ML
PROVIDER: S-EPMC5748851 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Sulciner Megan L ML Serhan Charles N CN Gilligan Molly M MM Mudge Dayna K DK Chang Jaimie J Gartung Allison A Lehner Kristen A KA Bielenberg Diane R DR Schmidt Birgitta B Dalli Jesmond J Greene Emily R ER Gus-Brautbar Yael Y Piwowarski Julia J Mammoto Tadanori T Zurakowski David D Perretti Mauro M Sukhatme Vikas P VP Kaipainen Arja A Kieran Mark W MW Huang Sui S Panigrahy Dipak D
The Journal of experimental medicine 20171130 1
Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer therapy is inherently a double-edged sword. In this study, we show that tumor cells killed by chemotherapy or targeted therapy ("tumor cell debris") stimulate primary tumor growth when coinjected with a subthreshold (nontumorigenic) inoculum of tumor cells by triggering macrophage proinflammatory cytokine release a ...[more]