Ontology highlight
ABSTRACT:
SUBMITTER: Ohsaki A
PROVIDER: S-EPMC5748859 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Ohsaki Asa A Venturelli Nicholas N Buccigrosso Tess M TM Osganian Stavroula K SK Lee John J Blumberg Richard S RS Oyoshi Michiko K MK
The Journal of experimental medicine 20171120 1
The role of maternal immune responses in tolerance induction is poorly understood. To study whether maternal allergen sensitization affects offspring susceptibility to food allergy, we epicutaneously sensitized female mice with ovalbumin (OVA) followed by epicutaneous sensitization and oral challenge of their offspring with OVA. Maternal OVA sensitization prevented food anaphylaxis, OVA-specific IgE production, and intestinal mast cell expansion in offspring. This protection was mediated by neon ...[more]