Ontology highlight
ABSTRACT:
SUBMITTER: Shi R
PROVIDER: S-EPMC5753038 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Shi Rongxin R Mullins Elwood A EA Shen Xing-Xing XX Lay Kori T KT Yuen Philip K PK David Sheila S SS Rokas Antonis A Eichman Brandt F BF
The EMBO journal 20171020 1
DNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications, and thus, the mechanisms by which glycosylases locate DNA damage are of particular interest. Bacterial AlkC and AlkD are specific for cationic alkylated nucleobases and have a distinctive HEAT-like repeat (HLR) fold. AlkD uses a unique non-base-flipping mechanism that enables excision of bulky lesions more commonly associated with nucleotide excision ...[more]