Dataset Information

Cavum Vergae, Liability, and Steroid Treatment: Manic Episode, Brain Imaging Findings, and Clinical Follow-up of a Systemic Lupus Erythematosus Case.

ABSTRACT: Systemic lupus erythematosus (SLE) or Lupus is a chronic and idiopathic autoimmune connective tissue disease that involves several organs and organ systems. SLE may lead to a group of psychiatric manifestations, including delirium, anxiety disorders, cognitive dysfunction, mood disorders, and psychosis, which are caused by organic or non-organic factors. In addition, it is thought that the most common cause of neuropsychiatric lupus is corticosteroid use; central nervous system involvement and inflammatory processes also have an important role in the development of psychiatric manifestations. In other respects, structural brain abnormalities induce proneness to psychotic and manic symptoms. Along with this proneness, cavum vergae, an anomaly closely related to the anatomic areas associated with mood regulation, may precipitate manic symptoms. In this case report, we present a manic episode case emerging after delirium, with a 1-year history of SLE, which has recently been diagnosed with cavum vergae and discuss the process of infection and corticosteroid treatment, which contributed to the proneness effect of a structural brain anomaly.

SUBMITTER: Misir E

PROVIDER: S-EPMC5758084 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Cavum Vergae, Liability, and Steroid Treatment: Manic Episode, Brain Imaging Findings, and Clinical Follow-up of a Systemic Lupus Erythematosus Case.

Misir Emre E Binbay İbrahim Tolga İT Targitay Bilge B Arat Hidayet Ece HE Can Gerçek G Alptekin Köksal K

Noro psikiyatri arsivi 20171201 4

Systemic lupus erythematosus (SLE) or Lupus is a chronic and idiopathic autoimmune connective tissue disease that involves several organs and organ systems. SLE may lead to a group of psychiatric manifestations, including delirium, anxiety disorders, cognitive dysfunction, mood disorders, and psychosis, which are caused by organic or non-organic factors. In addition, it is thought that the most common cause of neuropsychiatric lupus is corticosteroid use; central nervous system involvement and i ...[more]

PMID: 29321714

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Project description:IntroductionPatients with systemic lupus erythematous were vulnerable to severe coronavirus disease 2019 infection and the negative impact of disrupted healthcare delivery. Telemedicine has been a popular alternative to standard in-person care during the pandemic despite the lack of evidence.MethodsThis was a 1-year pragmatic randomized-controlled trial. Patients followed at the lupus nephritis clinic were randomized to either telemedicine or standard follow-up in a 1:1 ratio. Patients in the telemedicine group were followed up via videoconferencing. Standard follow-up group patients continued conventional in-person outpatient care. The primary outcome of the study was the proportion of patients in low disease activity after 1 year. Secondary outcomes included cost-of-illness, safety, and various patient-reported outcomes.ResultsFrom 6/2020 to 12/2021, 144 patients were randomized and 141 patients (telemedicine: 70, standard follow-up: 71) completed the study. At 1 year, 80.0% and 80.2% of the patients in the telemedicine group and standard follow-up group were in lupus low disease activity state or complete remission, respectively (p = 0.967). Systemic lupus erythematous disease activity indices, number of flares and frequency of follow-ups were also similar. There were no differences in the cost-of-illness, quality of life or mental health scores. However, significantly more patients in the telemedicine group (41.4% vs 5.6%; p < 0.001) required switch of mode of follow-up and higher proportion of them had hospitalization during the study period (32.9% vs 15.5%; p = 0.016). Being in the telemedicine group or not in low disease activity at baseline were the independent predictors of hospitalization (odds ratio: 2.6; 95% confidence interval: 1.1-6.1, odds ratio: 2.7, 95% confidence interval: 1.1-6.7, respectively) in the post hoc analysis.ConclusionsIn patients with systemic lupus erythematous, telemedicine predominant follow-up resulted in similar 1-year disease control compared to standard care. However, it needed to be complemented by in-person visits, especially in patients with unstable disease.

Dataset Information

Cavum Vergae, Liability, and Steroid Treatment: Manic Episode, Brain Imaging Findings, and Clinical Follow-up of a Systemic Lupus Erythematosus Case.

Publications

Cavum Vergae, Liability, and Steroid Treatment: Manic Episode, Brain Imaging Findings, and Clinical Follow-up of a Systemic Lupus Erythematosus Case.

Similar Datasets

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