Ontology highlight
ABSTRACT:
SUBMITTER: Di Pascale F
PROVIDER: S-EPMC5758869 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Nucleic acids research 20180101 1
MicroRNA-138 (miR-138) is a pro-survival oncomiR for glioma stem cells. In malignant gliomas, dysregulated expression of microRNAs, such as miR-138, promotes Tumour initiation and progression. Here, we identify the ancillary role of the CCAAT/enhancer binding protein β (C/EBPβ) as a transcriptional activator of miR-138. We demonstrate that a short 158 bp DNA sequence encoding the precursor of miR-138-2 is essential and sufficient for transcription of miR-138. This short sequence includes the A-b ...[more]