Ontology highlight
ABSTRACT:
SUBMITTER: Ren B
PROVIDER: S-EPMC5758876 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Ren Bingbing B Tan Hwei Ling HL Nguyen Thi Thuy Trang TTT Sayed Ahmed Mahmoud Mohammed AMM Li Ying Y Mok Yu-Keung YK Yang Henry H Chen Ee Sin ES
Nucleic acids research 20180101 1
Heterochromatin silencing is critical for genomic integrity and cell survival. It is orchestrated by chromodomain (CD)-containing proteins that bind to methylated histone H3 lysine 9 (H3K9me), a hallmark of heterochromatin. Here, we show that phosphorylation of tyrosine 41 (H3Y41p)-a novel histone H3 modification-participates in the regulation of heterochromatin in fission yeast. We show that a loss-of-function mutant of H3Y41 can suppress heterochromatin de-silencing in the centromere and subte ...[more]