Ontology highlight
ABSTRACT:
SUBMITTER: Stumme-Diers MP
PROVIDER: S-EPMC5758880 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Stumme-Diers Micah P MP Banerjee Siddhartha S Hashemi Mohtadin M Sun Zhiqiang Z Lyubchenko Yuri L YL
Nucleic acids research 20180101 1
In the absence of a functioning centromere, chromosome segregation becomes aberrant, leading to an increased rate of aneuploidy. The highly specific recognition of centromeres by kinetochores suggests that specific structural characteristics define this region, however, the structural details and mechanism underlying this recognition remains a matter of intense investigation. To address this, high-speed atomic force microscopy was used for direct visualization of the spontaneous dynamics of CENP ...[more]