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MEF2 signaling and human diseases.


ABSTRACT: The members of myocyte Enhancer Factor 2 (MEF2) protein family was previously believed to function in the development of heart and muscle. Recent reports indicate that they are also closely associated with development and progression of many human diseases. Although their role in cancer biology is well established, the molecular mechanisms underlying their action is yet largely unknown. MEF2 family is closely associated with various signaling pathways, including Ca2+ signaling, MAP kinase signaling, Wnt signaling, PI3K/Akt signaling, etc. microRNAs also contribute to regulate the activities of MEF2. In this review, we summarize the known molecular mechanism by which MEF2 family contribute to human diseases.

SUBMITTER: Chen X 

PROVIDER: S-EPMC5762387 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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MEF2 signaling and human diseases.

Chen Xiao X   Gao Bing B   Ponnusamy Murugavel M   Lin Zhijuan Z   Liu Jia J  

Oncotarget 20171204 67


The members of myocyte Enhancer Factor 2 (MEF2) protein family was previously believed to function in the development of heart and muscle. Recent reports indicate that they are also closely associated with development and progression of many human diseases. Although their role in cancer biology is well established, the molecular mechanisms underlying their action is yet largely unknown. MEF2 family is closely associated with various signaling pathways, including Ca<sup>2+</sup> signaling, MAP ki  ...[more]

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