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Maturation of the gut microbiome and risk of asthma in childhood.

ABSTRACT: The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.

SUBMITTER: Stokholm J

PROVIDER: S-EPMC5762761 | biostudies-other | 2018 Jan

REPOSITORIES: biostudies-other

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Maturation of the gut microbiome and risk of asthma in childhood.

Stokholm Jakob J Blaser Martin J MJ Thorsen Jonathan J Rasmussen Morten A MA Waage Johannes J Vinding Rebecca K RK Schoos Ann-Marie M AM Kunøe Asja A Fink Nadia R NR Chawes Bo L BL Bønnelykke Klaus K Brejnrod Asker D AD Mortensen Martin S MS Al-Soud Waleed Abu WA Sørensen Søren J SJ Bisgaard Hans H

Nature communications 20180110 1

The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 year ...[more]

PMID: 29321519

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