Ontology highlight
ABSTRACT:
SUBMITTER: Abramowski V
PROVIDER: S-EPMC5762856 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Abramowski Vincent V Etienne Olivier O Elsaid Ramy R Yang Junjie J Berland Aurélie A Kermasson Laetitia L Roch Benoit B Musilli Stefania S Moussu Jean-Paul JP Lipson-Ruffert Karelia K Revy Patrick P Cumano Ana A Boussin François D FD de Villartay Jean-Pierre JP
Cell death and differentiation 20171027 2
The repair of DNA double-stranded breaks (DNAdsb) through non-homologous end joining (NHEJ) is a prerequisite for the proper development of the central nervous system and the adaptive immune system. Yet, mice with Xlf or PAXX loss of function are viable and present with very mild immune phenotypes, although their lymphoid cells are sensitive to ionizing radiation attesting for the role of these factors in NHEJ. In contrast, we show here that mice defective for both Xlf and PAXX are embryonically ...[more]