Ontology highlight
ABSTRACT:
SUBMITTER: Messemaker TC
PROVIDER: S-EPMC5762901 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Scientific reports 20180110 1
The transcription factor Sox2 controls the fate of pluripotent stem cells and neural stem cells. This gatekeeper function requires well-regulated Sox2 levels. We postulated that Sox2 regulation is partially controlled by the Sox2 overlapping long non-coding RNA (lncRNA) gene Sox2ot. Here we show that the RNA levels of Sox2ot and Sox2 are inversely correlated during neural differentiation of mouse embryonic stem cells (ESCs). Through allele-specific enhanced transcription of Sox2ot in mouse Sox2e ...[more]