Ontology highlight
ABSTRACT:
SUBMITTER: Harris SE
PROVIDER: S-EPMC5764388 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
Harris Sarah E SE Riggio Valentina V Evenden Louise L Gilchrist Tamara T McCafferty Sarah S Murphy Lee L Wrobel Nicola N Taylor Adele M AM Corley Janie J Pattie Alison A Cox Simon R SR Martin-Ruiz Carmen C Prendergast James J Starr John M JM Marioni Riccardo E RE Deary Ian J IJ
Aging 20171201 12
Gene expression is influenced by both genetic variants and the environment. As individuals age, changes in gene expression may be associated with decline in physical and cognitive abilities. We measured transcriptome-wide expression levels in lymphoblastoid cell lines derived from members of the Lothian Birth Cohort 1936 at mean ages 70 and 76 years. Changes in gene expression levels were identified for 1,741 transcripts in 434 individuals. Gene Ontology enrichment analysis indicated an enrichme ...[more]