Cerebral hypoperfusion is not associated with an increase in amyloid ? pathology in middle-aged or elderly people.
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ABSTRACT:
SUBMITTER: Hansson O
PROVIDER: S-EPMC5766833 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Publications
Cerebral hypoperfusion is not associated with an increase in amyloid β pathology in middle-aged or elderly people.
Hansson Oskar O Palmqvist Sebastian S Ljung Hanna H Cronberg Tobias T van Westen Danielle D Smith Ruben R
Alzheimer's & dementia : the journal of the Alzheimer's Association 20170715 1
<h4>Introduction</h4>It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans.<h4>Methods</h4>Cerebral blood flow and amyloid β (<sup>18</sup>F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion of precerebral arteries resulting in chronic and uneven hypoperfusion. A subset ...[more]
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