Ontology highlight
ABSTRACT:
SUBMITTER: Langemeyer L
PROVIDER: S-EPMC5767875 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20171128 2
The identity of organelles in the endomembrane system of any eukaryotic cell critically depends on the correctly localized Rab GTPase, which binds effectors and thus promotes membrane remodeling or fusion. However, it is still unresolved which factors are required and therefore define the localization of the correct fusion machinery. Using SNARE-decorated proteoliposomes that cannot fuse on their own, we now demonstrate that full fusion activity can be achieved by just four soluble factors: a so ...[more]