Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia.
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ABSTRACT:
SUBMITTER: Estrada MA
PROVIDER: S-EPMC5767885 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
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Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia.
Estrada Michelle A MA Zhao Xiao X Lorent Kristin K Kriegermeier Alyssa A Nagao Seika A SA Berritt Simon S Wells Rebecca G RG Pack Michael M Winkler Jeffrey D JD
ACS medicinal chemistry letters 20171214 1
We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia. ...[more]
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