Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC5768685 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Zhang Shengzhe S Zhang Meiying M Jing Ying Y Yin Xia X Ma Pengfei P Zhang Zhenfeng Z Wang Xiaojie X Di Wen W Zhuang Guanglei G
Nature communications 20180115 1
MCL1 is a pivot member of the anti-apoptotic BCL-2 family proteins. While a distinctive feature of MCL1 resides in its efficient ubiquitination and destruction, the deubiquitinase USP9X has been implicated in the preservation of MCL1 expression by removing the polyubiquitin chains. Here we perform an unbiased siRNA screen and identify that the second deubiquitinase, USP13, regulates MCL1 stability in lung and ovarian cancer cells. Mechanistically, USP13 interacts with and stabilizes MCL1 via deu ...[more]