Ontology highlight
ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC5770342 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Han Yue Y Ishibashi Shoko S Iglesias-Gonzalez Javier J Chen Yaoyao Y Love Nick R NR Amaya Enrique E
Cell reports 20180101 1
While it is appreciated that reactive oxygen species (ROS) can act as second messengers in both homeostastic and stress response signaling pathways, potential roles for ROS during early vertebrate development have remained largely unexplored. Here, we show that fertilization in Xenopus embryos triggers a rapid increase in ROS levels, which oscillate with each cell division. Furthermore, we show that the fertilization-induced Ca<sup>2+</sup> wave is necessary and sufficient to induce ROS producti ...[more]