Ontology highlight
ABSTRACT:
SUBMITTER: Izuta Y
PROVIDER: S-EPMC5770878 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Izuta Yusuke Y Imada Toshihiro T Hisamura Ryuji R Oonishi Erina E Nakamura Shigeru S Inagaki Emi E Ito Masataka M Soga Tomoyoshi T Tsubota Kazuo K
Aging cell 20171109 1
Calorie restriction (CR) being the most robust dietary intervention provides various health benefits. D-3-hydroxybutyrate (3HB), a major physiological ketone, has been proposed as an important endogenous molecule for CR. To investigate the role of 3HB in CR, we investigated potential shared mechanisms underlying increased retinal 3HB induced by CR and exogenously applied 3HB without CR to protect against ischemic retinal degeneration. The repeated elevation of retinal 3HB, with or without CR, su ...[more]