Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5772774 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Wang Yajun Y Yun Chawon C Gao Beixue B Xu Yuanming Y Zhang Yana Y Wang Yiming Y Kong Qingfei Q Zhao Fang F Wang Chyung-Ru CR Dent Sharon Y R SYR Wang Jian J Xu Xiangping X Li Hua-Bin HB Fang Deyu D
Cell reports 20170701 3
The development of CD1d-restricted invariant natural killer T (iNKT) cells, a population that is critical for both innate and adaptive immunity, is regulated by multiple transcription factors, but the molecular mechanisms underlying how the transcriptional activation of these factors are regulated during iNKT development remain largely unknown. We found that the histone acetyltransferase general control non-derepressible 5 (GCN5) is essential for iNKT cell development during the maturation stage ...[more]