Unknown

Dataset Information

0

Contemporary Pharmacotherapy for Allergic Rhinitis and Chronic Rhinosinusitis.


ABSTRACT: Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are chronic conditions causing nasal inflammation. CRS is increasingly recognized as a chronic inflammatory process rather than a chronic infection. Although the primary initiating factors in CRS remain unclear, AR is driven by IgE-mediated hypersensitivity to environmental allergens. Understanding the underlying inflammatory pathways and disease endotypes are driving innovation toward novel pharmacotherapies targeting critical mediators implicated in CRS and AR, including IL-4, IL-13, IL-5, IgE, and epithelial initiators IL-33 and TSLP. Extensive investigations are needed to determine the role, timing, predictive prognostic factors and long-term safety and efficacy of these agents.

SUBMITTER: Ghadersohi S 

PROVIDER: S-EPMC5774623 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

altmetric image

Publications

Contemporary Pharmacotherapy for Allergic Rhinitis and Chronic Rhinosinusitis.

Ghadersohi Saied S   Tan Bruce K BK  

Otolaryngologic clinics of North America 20170928 6


Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are chronic conditions causing nasal inflammation. CRS is increasingly recognized as a chronic inflammatory process rather than a chronic infection. Although the primary initiating factors in CRS remain unclear, AR is driven by IgE-mediated hypersensitivity to environmental allergens. Understanding the underlying inflammatory pathways and disease endotypes are driving innovation toward novel pharmacotherapies targeting critical mediators im  ...[more]

Similar Datasets

| S-EPMC7387511 | biostudies-literature
| S-EPMC5798836 | biostudies-literature
| S-EPMC5514562 | biostudies-literature
| S-EPMC5103699 | biostudies-literature
| S-EPMC3833888 | biostudies-literature
| S-EPMC2847787 | biostudies-literature
| S-EPMC10667686 | biostudies-literature
| S-EPMC4399187 | biostudies-other
| S-EPMC4324099 | biostudies-literature
| S-EPMC10166850 | biostudies-literature