Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade.
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ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC5776803 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Publications
<i>Bifidobacterium</i> can mitigate intestinal immunopathology in the context of CTLA-4 blockade.
Wang Feng F Yin Qian Q Chen Liang L Davis Mark M MM
Proceedings of the National Academy of Sciences of the United States of America 20171218 1
Antibodies that attenuate immune tolerance have been used to effectively treat cancer, but they can also trigger severe autoimmunity. To investigate this, we combined anti-CTLA-4 treatment with a standard colitis model to give mice a more severe form of the disease. Pretreatment with an antibiotic, vancomycin, provoked an even more severe, largely fatal form, suggesting that a Gram-positive component of the microbiota had a mitigating effect. We then found that a commonly used probiotic, <i>Bifi ...[more]
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