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Risk for development of severe liver disease in lean patients with nonalcoholic fatty liver disease: A long-term follow-up study.

ABSTRACT: Most patients with nonalcoholic fatty liver disease (NAFLD) are overweight or obese. However, a significant proportion of patients have a normal body mass index (BMI), denoted as lean NAFLD. The long-term prognosis of lean NAFLD is unclear. We conducted a cohort study of 646 patients with biopsy-proven NAFLD. Patients were defined as lean (BMI?

SUBMITTER: Hagstrom H 

PROVIDER: S-EPMC5776871 | biostudies-other | 2018 Jan

REPOSITORIES: biostudies-other

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Risk for development of severe liver disease in lean patients with nonalcoholic fatty liver disease: A long-term follow-up study.

Hagström Hannes H   Nasr Patrik P   Ekstedt Mattias M   Hammar Ulf U   Stål Per P   Hultcrantz Rolf R   Kechagias Stergios S  

Hepatology communications 20171130 1

Most patients with nonalcoholic fatty liver disease (NAFLD) are overweight or obese. However, a significant proportion of patients have a normal body mass index (BMI), denoted as lean NAFLD. The long-term prognosis of lean NAFLD is unclear. We conducted a cohort study of 646 patients with biopsy-proven NAFLD. Patients were defined as lean (BMI < 25.0), overweight (BMI 25.0-29.9), or obese (BMI ≥ 30.0) at the time of biopsy. Each case was matched for age, sex, and municipality to 10 controls. Ove  ...[more]

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