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Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases.

ABSTRACT: This study presents a systematic meta-analysis of the correlation between Helicobacter pylori (H. pylori) infection and autoimmune thyroid diseases (AITD).Fifteen articles including 3,046 cases were selected (1,716 observational and 1,330 control cases). These data were analyzed using Stata12.0 meta-analysis software.H. pylori infection was positively correlated with the occurrence of AITD (OR = 2.25, 95% CI: 1.72-2.93). Infection with H. pylori strains positive for the cytotoxin-associated gene A (CagA) were positively correlated with AITD (OR = 1.99, 95% CI: 1.07-3.70). There was no significant difference between infections detected using enzyme-linked immunosorbent assay (ELISA) and other methods (?2 = 2.151, p = 0.143). Patients with Grave's disease (GD) and Hashimoto's thyroiditis (HT) were more susceptible to H. pylori infection (GD: OR = 2.78, 95% CI: 1.68-4.61; HT: OR = 2.16, 95% CI: 1.44-3.23), while the rate of H. pylori infection did not differ between GD and HT (?2 = 3.113, p = 0.078).H. pylori infection correlated with GD and HT, and the eradication of H. pylori infection could reduce thyroid autoantibodies.

SUBMITTER: Hou Y

PROVIDER: S-EPMC5777804 | biostudies-other | 2017 Dec

REPOSITORIES: biostudies-other

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Meta-analysis of the correlation between <i>Helicobacter pylori</i> infection and autoimmune thyroid diseases.

Hou Yi Y Sun Wen W Zhang Chengfei C Wang Tieshan T Guo Xuan X Wu Lili L Qin Lingling L Liu Tonghua T

Oncotarget 20171204 70

<h4>Objective</h4>This study presents a systematic meta-analysis of the correlation between <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection and autoimmune thyroid diseases (AITD).<h4>Materials and methods</h4>Fifteen articles including 3,046 cases were selected (1,716 observational and 1,330 control cases). These data were analyzed using Stata12.0 meta-analysis software.<h4>Results</h4>H. pylori infection was positively correlated with the occurrence of AITD (OR = 2.25, 95% CI: 1.72-2.93 ...[more]

PMID: 29383192

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Project description:OBJECTIVES:Many studies have explored the association between Helicobacter pylori infection and osteoporosis. However, the results remain controversial. Therefore, we performed this systematic review and meta-analysis to evaluate the association between H. pylori infection and osteoporosis. DESIGN:Systematic review and meta-analysis of case-control studies. DATA SOURCES:Databases, including PubMed, Embase, Web of Science and Chinese Biomedical Literature Database, were screened from inception to 30 April 2018. ELIGIBILITY CRITERIA:Case-control studies aimed at assessing the association between H. pylori infection and osteoporosis. DATA EXTRACTION AND ANALYSIS:Study characteristics and study quality sections were reviewed. Studies were selected, and data were extracted by two reviewers. Pooled ORs and 95% CIs were calculated using random effects model if heterogeneity existed; otherwise, fixed effects model was used. Subgroup analyses were performed to explore the source of heterogeneity. Publication bias and sensitivity analyses were also tested. RESULTS:A total of 21 studies with 9655 participants were included in our analyses. Taking together, we found that H. pylori infection was associated with increased odds of osteoporosis (OR (95% CI): 1.39 (1.13 to 1.71)); there was no significant difference between osteoporosis and osteopaenia; the association between osteoporosis and H. pylori infection was relatively higher in men than women but did not reach significant level. However, the decrease of bone mineral density in H. pylori-positive patients was not significant when compared with H. pylori negative controls, which may due to the sample size. CONCLUSIONS:Our meta-analysis suggests an association between osteoporosis and H. pylori infection. The clinicians should pay more attention to the patients infected with H. pylori. Further studies were still needed to exploring the confounding factors among studies and to elucidate the underlying biological mechanisms.

Dataset Information

Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases.

Publications

Meta-analysis of the correlation between <i>Helicobacter pylori</i> infection and autoimmune thyroid diseases.

Similar Datasets

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