Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigues J
PROVIDER: S-EPMC5778495 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Rodrigues Joana J Lydall David D
Nucleic acids research 20180101 2
The conserved PAF1 complex (Cdc73, Paf1, Ctr9, Leo1 and Rtf1, in yeast), binds RNA pol II, and affects levels of many RNAs. Although PAF1 is a complex, there is evidence that different components perform different functions. In yeast, Cdc73, Paf1 and Ctr9 maintain normal telomerase RNA (TLC1) levels and affect telomere length. Here we report a new connection between the PAF1 complex and telomere biology. We show that Paf1 and Ctr9 maintain low telomere repeat containing RNA (TERRA) levels while ...[more]