Ontology highlight
ABSTRACT:
SUBMITTER: Rubinsteyn A
PROVIDER: S-EPMC5778604 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Rubinsteyn Alex A Kodysh Julia J Hodes Isaac I Mondet Sebastien S Aksoy Bulent Arman BA Finnigan John P JP Bhardwaj Nina N Hammerbacher Jeffrey J
Frontiers in immunology 20180118
This paper describes the sequencing protocol and computational pipeline for the PGV-001 personalized vaccine trial. PGV-001 is a therapeutic peptide vaccine targeting neoantigens identified from patient tumor samples. Peptides are selected by a computational pipeline that identifies mutations from tumor/normal exome sequencing and ranks mutant sequences by a combination of predicted Class I MHC affinity and abundance estimated from tumor RNA. The personalized genomic vaccine (PGV) pipeline is mo ...[more]