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Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort.

ABSTRACT: OBJECTIVE:To evaluate the association between growth trajectories from birth to adolescence and cardiovascular risk marker levels at age 18 years in a population-based cohort. In order to disentangle the effect of weight gain from that of height gain, growth was analysed using conditional weight relative to linear growth (CWh) and conditional length/height (CH). DESIGN:Prospective study. SETTING:1993 Pelotas birth cohort, Southern Brazil. PARTICIPANTS:Individuals who have been followed up from birth to adolescence (at birth, 1, 4, 11, 15 and 18 years). PRIMARY OUTCOME MEASURES:C-reactive protein (CRP), total cholesterol (TC), LDL cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TGL), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and waist circumference (WC). RESULTS:In both sexes, greater CWh at 1?year was positively associated with BMI and WC, whereas greater CWh at most age periods in childhood and adolescence predicted higher CRP, TC, LDL-C, TGL, SBP, DBP, BMI and WC levels, as well as lower HDL-C level. Higher CH during infancy and childhood was positively related with SBP in boys and girls, and with BMI and WC only in boys. CONCLUSION:Our study shows that rapid weight gain from 1?year onwards is positively associated with several markers of cardiovascular risk at 18 years. Overall, our results for the first year of life add evidence to the 'first 1000 days initiative' suggesting that prevention of excessive weight gain in childhood might be important in reducing subsequent cardiovascular risk.

SUBMITTER: Buffarini R

PROVIDER: S-EPMC5786082 | biostudies-other | 2018 Jan

REPOSITORIES: biostudies-other

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Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort.

Buffarini Romina R Restrepo-Méndez María Clara MC Silveira Vera Maria VM Gonçalves Helen D HD Oliveira Isabel O IO Menezes Ana Maria AM Formoso Assunção Maria Cecília MC

BMJ open 20180123 1

<h4>Objective</h4>To evaluate the association between growth trajectories from birth to adolescence and cardiovascular risk marker levels at age 18 years in a population-based cohort. In order to disentangle the effect of weight gain from that of height gain, growth was analysed using conditional weight relative to linear growth (CWh) and conditional length/height (CH).<h4>Design</h4>Prospective study.<h4>Setting</h4>1993 Pelotas birth cohort, Southern Brazil.<h4>Participants</h4>Individuals who ...[more]

PMID: 29362264

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Project description:Evidence regarding the deleterious effects of diet on blood lipids in adolescence has been inconsistent, and few studies have investigated this association using a dietary pattern approach. We examined whether dietary pattern of adolescents are associated with blood lipid concentrations.Cross-sectional analysis of 3524 18-year-old participants in the 1993 Pelotas (Brazil) Birth Cohort Study. A semi-quantitative food frequency questionnaire was administered. Dietary patterns were established using principal component analysis and analysed as tertiles of factor scores. Independent associations between each dietary pattern tertile and blood lipid values (total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) were tested using adjusted linear regression models stratified by sex. Triglycerides were log-transformed due to their skewed distribution, and the beta coefficients should be interpreted as the % change (increase or decrease).Four dietary patterns were derived: Meat Products and Fast Foods; Fruits and Vegetables; Candies, Sodas and Dairy Products; and Common Brazilian Foods. In the adjusted models, which compared the highest and lowest tertiles of dietary pattern scores, we observed that among girls: 1) the third tertile of the Meat Products and Fast Foods pattern was associated with 1.5 mg/dL (95% CI -3.05; ?-0.04) lower HDL-cholesterol; 2) the second and third tertile of the Candies, Sodas and Dairy Products pattern was associated with 5% and 10% higher triglycerides (? 1.05, 95% CI 1.01; 1.09, ? 1.10, 95% CI 1.05; 1.16), respectively; 3) the second and third tertiles of the Common Brazilian Foods pattern were associated with 4 mg/dL (? -?4.30, 95% CI -7.75; ?-0.85, ? -?4.95, 95% CI -8.53; ?-1.36, respectively) lower total cholesterol and 6% lower triglycerides (? 0.94, 95% CI 0.90; 0.99, ? 0.93, 95% CI 0.89; 0.98, respectively). For boys, 4) the third tertile of the Common Brazilian Foods was associated with 4.6 mg/dL (95% CI -7.91; ?-1.37) lower total cholesterol and 3.8 mg/dL (95% CI -6.51; -?1.13) lower LDL-cholesterol.Dietary patterns were more closely associated with blood lipids among girls than boys at age 18. Higher scores for the Common Brazilian Foods pattern were associated with lower total cholesterol in both sexes.

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Dataset Information

Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort.

Publications

Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort.

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