Ontology highlight
ABSTRACT:
SUBMITTER: Dileep V
PROVIDER: S-EPMC5789892 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Nature communications 20180130 1
Mammalian DNA replication is regulated via multi-replicon segments that replicate in a defined temporal order during S-phase. Further, early/late replication of RDs corresponds to active/inactive chromatin interaction compartments. Although replication origins are selected stochastically, variation in replication timing is poorly understood. Here we devise a strategy to measure variation in replication timing using DNA copy number in single mouse embryonic stem cells. We find that borders betwee ...[more]