Ontology highlight
ABSTRACT:
SUBMITTER: Zhu B
PROVIDER: S-EPMC5790700 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Zhu Binan B Lu Yuting Y Chen Leilin L Yu Binbin B Liu Yuexin Y Song Min M Hang Taijun T
Journal of pharmaceutical analysis 20170331 4
A sensitive and selective method was developed for the separation and characterization of related substances (RSs) in EVT-401 by hyphenated LC-MS techniques. Complete separation of the RSs was achieved with an Inertsil ODS-SP column (250 mm×4.6 mm, 5 µm) by linear gradient elution using a mobile phase consisting of 0.2% formic acid solution, methanol and acetonitrile. EVT-401 was found to be susceptible to acid, alkaline and oxidative stresses, while relatively stable under photolytic and therma ...[more]