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Increased risk of coronary heart disease among patients with primary Sjogren's syndrome: a nationwide population-based cohort study.


ABSTRACT: To investigate the association between primary Sjögren's syndrome (pSS) and coronary heart disease (CHD), and the influence of medications for pSS patients on risk of CHD. The authors identified 4175 patients with a new diagnosis of pSS between 2002 and 2013 from the National Health Insurance Research database. The control-to-case ratio was 4:1. The risk and cumulative incidences of CHD were calculated. The adjusted hazard ratio (HR) of CHD for pSS patients was 1.17 (1.03-1.34) after adjusting for age, sex, comorbidities, and medications. The cumulative incidence for CHD in the pSS group was significantly higher than that in the control group (log-rank p?

SUBMITTER: Wu XF 

PROVIDER: S-EPMC5797247 | biostudies-other | 2018 Feb

REPOSITORIES: biostudies-other

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Increased risk of coronary heart disease among patients with primary Sjögren's syndrome: a nationwide population-based cohort study.

Wu Xue-Fen XF   Huang Jing-Yang JY   Chiou Jeng-Yuan JY   Chen Huang-Hsi HH   Wei James Cheng-Chung JC   Dong Ling-Li LL  

Scientific reports 20180202 1


To investigate the association between primary Sjögren's syndrome (pSS) and coronary heart disease (CHD), and the influence of medications for pSS patients on risk of CHD. The authors identified 4175 patients with a new diagnosis of pSS between 2002 and 2013 from the National Health Insurance Research database. The control-to-case ratio was 4:1. The risk and cumulative incidences of CHD were calculated. The adjusted hazard ratio (HR) of CHD for pSS patients was 1.17 (1.03-1.34) after adjusting f  ...[more]

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