Ontology highlight
ABSTRACT:
SUBMITTER: Luo J
PROVIDER: S-EPMC5797812 | biostudies-other | 2018 Feb
REPOSITORIES: biostudies-other
Luo Jing J Wang Zhongqiu Z Huang Jianfeng J Yao Yu Y Sun Qi Q Wang Jie J Shen Yi Y Xu Lin L Ren Binhui B
Cancer science 20171220 2
Esophageal squamous cell carcinoma (ESCC), the dominant subtype of esophageal cancer, is one of the most common digestive tumors worldwide. In this study, we confirmed that HOXC13, a member of the homeobox HOXC gene family, was significantly upregulated in ESCC and its overexpression was associated with poorer clinical characteristics and worse prognosis. Moreover, knockdown of HOXC13 inhibited proliferation and induced apoptosis of ESCC through upregulating CASP3. ChIP analysis revealed that HO ...[more]