Ontology highlight
ABSTRACT:
SUBMITTER: Gregor C
PROVIDER: S-EPMC5798359 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Gregor Carola C Gwosch Klaus C KC Sahl Steffen J SJ Hell Stefan W SW
Proceedings of the National Academy of Sciences of the United States of America 20180116 5
Bioluminescence imaging of single cells is often complicated by the requirement of exogenous luciferins that can be poorly cell-permeable or produce high background signal. Bacterial bioluminescence is unique in that it uses reduced flavin mononucleotide as a luciferin, which is abundant in all cells, making this system purely genetically encodable by the <i>lux</i> operon. Unfortunately, the use of bacterial bioluminescence has been limited by its low brightness compared with other luciferases. ...[more]