Ontology highlight
ABSTRACT:
SUBMITTER: Kawasaki N
PROVIDER: S-EPMC5798889 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Kawasaki Natsumi N Isogaya Kazunobu K Dan Shingo S Yamori Takao T Takano Hiroshi H Yao Ryoji R Morishita Yasuyuki Y Taguchi Luna L Morikawa Masato M Heldin Carl-Henrik CH Noda Tetsuo T Ehata Shogo S Miyazono Kohei K Koinuma Daizo D
Cell discovery 20180109
The mammalian target of rapamycin (mTOR) pathway is commonly activated in human cancers. The activity of mTOR complex 1 (mTORC1) signaling is supported by the intracellular positioning of cellular compartments and vesicle trafficking, regulated by Rab GTPases. Here we showed that tuftelin 1 (TUFT1) was involved in the activation of mTORC1 through modulating the Rab GTPase-regulated process. TUFT1 promoted tumor growth and metastasis. Consistently, the expression of TUFT1 correlated with poor pro ...[more]